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Enantioselective Bioaccumulation and Toxicity of the Neonicotinoid Insecticide Dinotefuran in Earthworms (Eisenia fetida)

Author:
Liu, Tong, Chen, Dan, Li, Yiqiang, Wang, Xiuguo, Wang, Fenglong
Source:
Journal of agricultural and food chemistry 2018 v.66 no.17 pp. 4531-4540
ISSN:
1520-5118
Subject:
Eisenia fetida, acute toxicity, bioaccumulation, dinotefuran, earthworms, edaphic factors, enantiomers, enantioselectivity, endoplasmic reticulum, oxidative stress, reproduction, risk, soil, transcriptomics
Abstract:
The enantioselective bioaccumulation and toxicity of dinotefuran in earthworms were studied in this study. The results showed that S-dinotefuran accumulated faster than Rac-dinotefuran and R-dinotefuran in earthworms. The acute toxicity of S-dinotefuran was 1.49 and 2.67 times that of the Rac-dinotefuran and R-dinotefuran in artificial soil during 14 days of exposure. At 1.0 mg/kg, the three tested chemicals inhibited the growth and reproduction as well as induced oxidative stress effects in earthworms; however, the toxic effects induced by S-dinotefuran were the most serious. The transcriptome sequencing results showed that S-dinotefuran had stronger interactions to biomacromolecules and influences on the endoplasmic reticulum (ER) than R-dinotefuran, which may be the main reason for enantioselectivities between the two enantiomers. The present results indicated that the risk of S-dinotefuran was higher than that of Rac-dinotefuran and R-dinotefuran in the soil environment to earthworms. Risk assessment of dinotefuran should be evaluated at the enantiomer level.
Agid:
6042651