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Cornusides A–O, Bioactive Iridoid Glucoside Dimers from the Fruit of Cornus officinalis

Xian-Sheng Ye, Jun He, Yung-Chi Cheng, Lei Zhang, Hao-Yi Qiao, Xue-Ge Pan, Jia Zhang, Shu-Na Liu, Wei-Ku Zhang, Jie-Kun Xu
Journal of natural products 2017 v.80 no.12 pp. 3103-3111
Cornus officinalis, chemical structure, fruits, glucosides, human cell lines, inhibitory concentration 50, iridoid glycosides, nuclear magnetic resonance spectroscopy, spectral analysis
Fifteen new and rare iridoid glucoside dimers, cornusides A–O (1–15), and 10 known iridoid glucosides (16–25) were isolated from the fruit of Cornus officinalis. These new chemical structures were established through spectroscopic analysis (UV, IR, HRESIMS, 1D and 2D NMR). Compounds 1–25 were tested for their inhibitory activities by measuring IL-6-induced STAT3 promoter activity in HepG2 cells, and 3, 12, 17, 22, and 23 showed inhibitory effects, with IC₅₀ values of 11.9, 12.2, 14.0, 7.0, and 6.9 μM, respectively.