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Hamigerans R and S: Nitrogenous Diterpenoids from the New Zealand Marine Sponge Hamigera tarangaensis
- Woolly, Ethan F., Singh, A. Jonathan, Russell, Euan R., Miller, John H., Northcote, Peter T.
- Journal of natural products 2018 v.81 no.2 pp. 387-393
- Porifera, carbon, diterpenoids, nitrogen, New Zealand
- Seven new members of the hamigeran family of diterpenoids have been isolated from the New Zealand marine sponge Hamigera tarangaensis. Among the new additions are hamigeran R (1), considered to be the first benzonitrile-based marine natural product, and hamigeran S (2), the first dimeric structure in the series. The formation of 1 and 2 is thought to occur via the reaction of hamigeran G with a nitrogen source, where the nitrile carbon of 1 is derived from the terpenoid skeleton.