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Iridoids from the Roots of Patrinia scabra and Their Inhibitory Potential on LPS-Induced Nitric Oxide Production

Author:
Lee, Da Hye, Shin, Ji-Sun, Kang, Shin-Young, Lee, Seung-Bin, Lee, Jin Su, Ryu, Seung Mok, Lee, Kyung Tae, Lee, Dongho, Jang, Dae Sik
Source:
Journal of natural products 2018 v.81 no.6 pp. 1468-1473
ISSN:
1520-6025
Subject:
Patrinia, ethanol, fractionation, inhibitory concentration 50, iridoids, lignans, nitric oxide, nuclear magnetic resonance spectroscopy, plant extracts, roots, spectral analysis
Abstract:
An activity-guided fractionation procedure of the 70% aqueous EtOH extract from the roots of Patrinia scabra led to the isolation and characterization of five new iridoids, patriscabrins A–E (1–5), along with 13 known compounds. The structures of 1–5 were determined by interpretation of spectroscopic data, particularly by 1D and 2D NMR, ECD, and VCD studies. Thereafter, isolates were evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. Of these, the new iridoids 2 and 5 and the known lignan patrineolignan B (6) exhibited IC₅₀ values of 14.7 to 17.8 μM.
Agid:
6043173