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Anti-Tobacco Mosaic Virus Quassinoids from Ailanthus altissima (Mill.) Swingle

Author:
Tan, Qing-Wei, Ni, Jian-Cheng, Zheng, Lu-Ping, Fang, Pei-Hua, Shi, Jian-Ting, Chen, Qi-Jian
Source:
Journal of agricultural and food chemistry 2018 v.66 no.28 pp. 7347-7357
ISSN:
1520-5118
Subject:
Ailanthus altissima, Nicotiana benthamiana, Western blotting, coat proteins, fruits, glycosides, viruses
Abstract:
Quassinoids are bitter constituents characteristic of the family Simaroubaceae. A total of 18 C₂₀ quassinoids, including nine new quassinoid glycosides, named chuglycosides A–I (1–6 and 8–10), were identified from the samara of Ailanthus altissima (Mill.) Swingle. All of the quassinoids showed potent anti-tobacco mosaic virus (TMV) activity. A preliminary structure–anti-TMV activity relationship of quassinoids was discussed. The effects of three quassinoids, including chaparrinone (12), glaucarubinone (15), and ailanthone (16), on the accumulation of TMV coat protein (CP) were studied by western blot analysis. Ailanthone (16) was further investigated for its influence on TMV spread in the Nicotiana benthamiana plant.
Agid:
6049052