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Anti-thrombogenicity and permeability of polyethersulfone hollow fiber membrane with sulfonated alginate toward blood purification

Author:
Salimi, Esmaeil, Ghaee, Azadeh, Ismail, Ahmad Fauzi, Karimi, Majid
Source:
International journal of biological macromolecules 2018 v.116 pp. 364-377
ISSN:
0141-8130
Subject:
adhesion, amination, biocompatibility, blood platelets, cell adhesion, coagulation, coatings, cross-linking reagents, glutaraldehyde, hydrophilicity, permeability, sodium alginate, toxins
Abstract:
The main aim of this study was to evaluate the suitability of sulfonated alginate as a modifying agent to enhance the hemocompatibility of self-fabricated polyethersulfone (PES) hollow fiber membrane for blood detoxification. Sodium alginate was sulfonated with a degree of 0.6 and immobilized on the membrane via surface amination and using glutaraldehyde as cross-linking agent. Coating layer not only improved the membrane surface hydrophilicity, but also induced −39.2 mV negative charges on the surface. Water permeability of the modified membrane was enhanced from 67 to 95 L/m²·h·bar and flux recovery ratio increased more than 2-fold. Furthermore, the modified membrane presented higher platelet adhesion resistance (reduced by more than 90%) and prolonged coagulation time (35 s for APTT and 14 s for PT) in comparison with the pristine PES hollow fiber membrane, which verified the improved anti-thrombogenicity of the modified membrane. On the other hand, obtained membrane after 3 h coating could remove up-to 60% of the uremic toxins. According to the obtained data, sulfonated alginate can be a promising modifying agent for the future blood-contacting membrane and specially blood purification issues.
Agid:
6052829