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Anti-thrombogenicity and permeability of polyethersulfone hollow fiber membrane with sulfonated alginate toward blood purification

Salimi, Esmaeil, Ghaee, Azadeh, Ismail, Ahmad Fauzi, Karimi, Majid
International journal of biological macromolecules 2018 v.116 pp. 364-377
adhesion, amination, biocompatibility, blood platelets, cell adhesion, coagulation, coatings, cross-linking reagents, glutaraldehyde, hydrophilicity, permeability, sodium alginate, toxins
The main aim of this study was to evaluate the suitability of sulfonated alginate as a modifying agent to enhance the hemocompatibility of self-fabricated polyethersulfone (PES) hollow fiber membrane for blood detoxification. Sodium alginate was sulfonated with a degree of 0.6 and immobilized on the membrane via surface amination and using glutaraldehyde as cross-linking agent. Coating layer not only improved the membrane surface hydrophilicity, but also induced −39.2 mV negative charges on the surface. Water permeability of the modified membrane was enhanced from 67 to 95 L/m²·h·bar and flux recovery ratio increased more than 2-fold. Furthermore, the modified membrane presented higher platelet adhesion resistance (reduced by more than 90%) and prolonged coagulation time (35 s for APTT and 14 s for PT) in comparison with the pristine PES hollow fiber membrane, which verified the improved anti-thrombogenicity of the modified membrane. On the other hand, obtained membrane after 3 h coating could remove up-to 60% of the uremic toxins. According to the obtained data, sulfonated alginate can be a promising modifying agent for the future blood-contacting membrane and specially blood purification issues.