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Simultaneous qualitative and quantitative analysis of fluoroalkyl sulfonates in riverine water by liquid chromatography coupled with Orbitrap high resolution mass spectrometry

Author:
Lin, Yongfeng, Liu, Runzeng, Hu, Fanbao, Liu, Ruirui, Ruan, Ting, Jiang, Guibin
Source:
Journal of chromatography 2016 v.1435 pp. 66-74
ISSN:
0021-9673
Subject:
anion exchange, estuaries, isomers, liquid chromatography, mass spectrometry, perfluorocarbons, quantitative analysis, rivers, screening, solid phase extraction, spectrometers, sulfonates
Abstract:
In this study, a robust method for quick screening, confirmation and quantification analysis of eight fluoroalkyl sulfonates in surface riverine samples was developed using ultra-high performance liquid chromatography-high resolution mass spectrometer (LC-Orbitrap Tribrid HRMS). Weak anion exchange solid phase extraction was optimized to maximum recover perfluoroalkyl sulfonates (PFSAs), fluorotelomer sulfonates and the emerging 6:2 chlorinated polyfluoroalkyl ether sulfonate at the same time. Both qualitative and quantitative purposes could be achieved by simultaneous acquiring full-scan mass spectrum (MS¹) and data-dependent MS² data. The LC-Orbitrap Tribrid HRMS method showed competent method detection limits for all analytes (7.1–62pg/L) compared with the triple quadrupole mass spectrometry (LC–MS/MS) quantification method (12–54pg/L), and satisfactory method validation results were also obtained in linearity (R²>0.999), trueness (88–118%), precision (2–17%) and recovery (63–103%). A good correlation (R>0.999) was found between the sets of quantified PFSA residue concentrations in thirteen estuary river samples by both the LC-Orbitrap Tribrid HRMS (0.2–440ng/L) and LC–MS/MS (0.1–424ng/L) methods, indicating that Orbitrap Tribrid HRMS could be used for reliable quantitative analysis purpose. Moreover, the LC-Orbitrap Tribrid HRMS method could also benefit from its high mass resolution characteristic to eliminate potential environment interferents (e.g., taurodeoxycholate) and to quantify all PFSA isomers based on full-scan MS¹ chromatogram at a narrow MS window (5 part per million).
Agid:
6057325