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Au nanorods modulated NIR fluorescence and singlet oxygen generation of water soluble dendritic zinc phthalocyanine

Author:
Zhou, Xuefei, He, Xiaohong, Wei, Shiliang, Jia, Kun, Liu, Xiaobo
Source:
Journal of colloid and interface science 2016 v.482 pp. 252-259
ISSN:
0021-9797
Subject:
aqueous solutions, carboxylation, cetyltrimethylammonium bromide, dimethylformamide, dyes, electrostatic interactions, fluorescence, gold, nanogold, nanorods, photochemotherapy, photosensitizing agents, singlet oxygen, solvents, water solubility
Abstract:
A novel cyano-terminated zinc phthalocyanine (ZnPc-CN) exhibiting visible near infrared (vis-NIR) emitting around 690nm in N,N-dimethylformamide (DMF) solvent has been synthesized. Furthermore, the peripheral cyano groups of newly synthesized zinc phthalocyanine were hydrolyzed in strong basic solution, leading to water soluble carboxylated zinc phthalocyanine (ZnPc-COOH) with completely quenched fluorescence in aqueous solution. Interestingly, we found that the NIR fluorescence of aqueous ZnPc-COOH was dramatically recovered in the presence of gold nanorods (Au NR), which was due to the alternation of ZnPc-COOH molecules self-assembling via electrostatic interaction between cetyltrimethylammonium bromide (CTAB) on the surface of Au NR and peripheral carboxyl of ZnPc-COOH. In addition, ZnPc-COOH/Au NR conjugates demonstrated an improved singlet oxygen generation, which could be served as potential bioimaging probe and photosensitizer for photodynamic therapy.
Agid:
6058961