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Silica Ammonium Acetate(SiO2-NH4OAc) Catalyzed Facial Synthesis of Dihydropyrazolo[4',3':5,6]Pyrano[2,3-d]Pyrimidine-5,7-Diones

Author:
Rigi, Fatemeh, Shaterian, Hamid Reza
Source:
Acta Chemica Iasi 2018 v.26 no.1 pp. 45-58
ISSN:
2067-2446
Subject:
acetoacetic acid, aldehydes, ammonium acetate, catalysts, filtration, hydrazine, recycling, silica
Abstract:
Silica ammonium acetate (SiO₂-NH₄OAc) was applied as an inexpensive, practical and heterogeneous catalyst for the preparation of new and known dihydropyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidine-5,7-diones via one-pot four-component reaction of hydrazine hydrate, ethyl acetoacetate aldehydes and barbituric acid/dimethyl barbituric acid under solvent-free conditions. Silica supported ammonium acetate (SiO₂-NH₄OAc) was prepared according to easy procedure under ambient condition. After completion of the reaction, the catalyst was separated by filtration and reused. So, recycling system, simple work-up, using non-toxic materials, excellent yields and short reaction times makes our research green and convenient for preparation of these classes of organic compounds.
Agid:
6060463