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Hydroxytyrosol and tyrosol esters partitioning into, location within, and effect on DOPC liposome bilayer behavior

Author:
Kervin O. Evans, Joseph A. Laszlo, David L. Compton
Source:
Biochimica et Biophysica Acta - Biomembranes 2015 v.1848 no.5 pp. 1175-1182
ISSN:
0005-2736
Subject:
antioxidants, cell membranes, cuphea seed oil, decanoic acid, esters, olive oil, phenols
Abstract:
The phenols hydroxytyrosol and tyrosol made abundantly available through olive oil processing were enzymatically transesterified into effective lipophilic antioxidants with cuphea oil. The hydroxytyrosyl and tyrosyl esters made from cuphea oil were assessed for their ability to partition into, locate within, and effect the bilayer behavior of 1,2-dioloeoylphosphatidylcholine liposomes compared to their counterparts made from decanoic acid. Partitioning into liposomes was on the same scale for both hydroxytyrosyl derivatives and both tyrosyl derivatives. All were found to locate nearly at the same depth within the bilayer. Each was found to affect bilayer behavior in a distinct manner.
Agid:
60626
Handle:
10113/60626