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An experimental and numerical modeling study of tribocharging in pharmaceutical granular mixtures

Author:
Naik, Shivangi, Sarkar, Saurabh., Hancock, Bruno, Rowland, Martin, Abramov, Yuriy, Yu, Weili, Chaudhuri, Bodhisattwa
Source:
Powder technology 2016 v.297 pp. 211-219
ISSN:
0032-5910
Subject:
electrostatic interactions, ibuprofen, manufacturing, mathematical models, powders
Abstract:
Most pharmaceutical powders are dielectric materials that often accumulate charge during manufacturing process. In this study, triboelectrification of binary mixtures of drug and excipient has been investigated. Powder samples for charge measurement were mixed using a V-blender and dispensed directly into a Faraday cup. The mixtures at intermediate concentration exhibited significant charge mitigation. These unanticipated trends previously reported have been explored using process modeling approaches. Additionally, in silico computations have been performed to estimate the work function of the all contact materials. DEM simulations suggest that the drug particles (Ibuprofen) charge positively whereas the excipient (MCC) charges negatively when particle-particle collisions become substantial. This charge transfer is suspected to actually enhance electrostatic interaction between the drug and excipient and decrease the overall charge transfer between particle and wall.
Agid:
6062602