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Assessment of glutathione peroxidase-1 polymorphisms, oxidative stress and DNA damage in sensitivity-related illnesses

Author:
Gugliandolo, Agnese, Gangemi, Chiara, Calabrò, Carlo, Vecchio, Mercurio, Di Mauro, Debora, Renis, Marcella, Ientile, Riccardo, Currò, Monica, Caccamo, Daniela
Source:
Life sciences 2016 v.145 pp. 27-33
ISSN:
0024-3205
Subject:
DNA damage, DNA fragmentation, antioxidants, genotype, glutathione, glutathione peroxidase, oxidation, oxidative stress, patients, ubiquinones
Abstract:
Oxidative stress increase is a key event for development of sensitivity-related illnesses (SRIs). The aim of this work was to evaluate the influence of a genetic variant in the antioxidant enzyme glutathione peroxidase (GPx1) on oxidative stress development in SRIs.GPx1 rs1800668 genotype, as well as glutathione, ubiquinone, and DNA damage were assessed in 34 SRI patients and 36 healthy subjects.Total glutathione, reduced/oxidized glutathione, and ubiquinone were significantly decreased in cases compared with controls, while DNA fragmentation was significantly increased in patients. However, these differences were not associated to GPx1 genetic background.GPx1 rs1800668 polymorphism does not play a major role in SRI-related oxidative stress development.
Agid:
6062977