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Reversible Self-Assembled Monolayers (rSAMs) as Robust and Fluidic Lipid Bilayer Mimics

Yeung, Sing Yee, Ederth, Thomas, Pan, Guoqing, Cicėnaitė, Judita, Cárdenas, Marité, Arnebrant, Thomas, Sellergren, Börje
Langmuir 2018 v.34 no.13 pp. 4107-4115
air, biomimetics, biosensors, carbohydrates, decane, lipid bilayers, lipids, liquids, models, proteins
Lipid bilayers, forming the outer barrier of cells, display a wide array of proteins and carbohydrates for modulating interfacial biological interactions. Formed by the spontaneous self-assembly of lipid molecules, these bilayers feature liquid crystalline order, while retaining a high degree of lateral mobility. Studies of these dynamic phenomena have been hampered by the fragility and instability of corresponding biomimetic cell membrane models. Here, we present the construct of a series of oligoethylene glycol-terminated reversible self-assembled monolayers (rSAMs) featuring lipid-bilayer-like fluidity, while retaining air and protein stability and resistance. These robust and ordered layers were prepared by simply immersing a carboxylic acid-terminated self-assembled monolayer into 5–50 μM aqueous ω-(4-ethylene glycol-phenoxy)-α-(4-amidinophenoxy)decane solutions. It is anticipated that this new class of robust and fluidic two-dimensional biomimetic surfaces will impact the design of rugged cell surface mimics and high-performance biosensors.