Main content area

Self-Assembled Magnetic Viruslike Particles for Encapsulation and Delivery of Deoxyribonucleic Acid

Zhao, Wenrong, Sun, Hong, Wang, Yitong, Eastoe, Julian, Dong, Shuli, Hao, Jingcheng
Langmuir 2018 v.34 no.24 pp. 7171-7179
DNA, absorption, cationic surfactants, encapsulation, magnetic fields, magnetic properties, myoglobin, nanoparticles
Developing nontoxic artificial carriers for stimuli-responsive capture, transport, and delivery of biomolecules is of immense scientific interest. Herein, for the first time, we synthesize a double-tailed cationic surfactant, (C₁₆H₃₃)₂(CH₃)₂N⁺[FeCl₃Br]⁻, which possesses magnetic properties [magnetic surfactants (Mag-Surfs)]. The time-dependent formation of virus-shaped hybrid mixed assemblies of polyoxometalates (POMs) {Mo₇₂Fe₃₀}/Mag-Surf with hollow-shell structures is followed. These structures serve well as robust high-surface-area shuttles, which can be manipulated with applied magnetic fields. By using cationic Mag-Surfs, the anionic POMs and DNA can be complexed in these ternary mixtures. These virus-shaped complexes act as nanoanchors and nanomotors, which can be utilized for binding, anchoring, and delivery of biomolecules, such as DNA. It is found that they have a good absorption capacity for DNA and myoglobin over 24 h, after application of a magnetic field. The realization of magnetic virus-shaped {Mo₇₂Fe₃₀}/Mag-Surf spheres may open possibilities for designing other functional nanoparticles, allowing effective control over the delivery/separation of biomolecules.