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Exploring the use of nanocarrier systems to deliver the magical molecule; Curcumin and its derivatives
- Mehanny, Mina, Hathout, Rania M., Geneidi, Ahmed S., Mansour, Samar
- Journal of controlled release 2016 v.225 pp. 1-30
- bioavailability, curcumin, drugs, metabolism, nanocarriers, photolysis, solubility
- Curcumin and its derivatives; curcuminoids have been proven as potential remedies in different diseases. However, their delivery carries several challenges owing to their poor aqueous solubility, photodegradation, chemical instability, poor bioavailability and rapid metabolism. This review explores and criticizes the numerous attempts that were adopted through the years to entrap/encapsulate this valuable drug in nanocarriers aiming to reach its most appropriate and successful delivery system.