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Safety of a thickened extensive casein hydrolysate formula
- Vandenplas, Yvan, De Greef, Elisabeth, Xinias, I., Vrani, O., Mavroudi, A., Hammoud, M., Al Refai, F., Khalife, M.C., Sayad, A., Noun, P., Farah, A., Makhoul, G., Orel, R., Sokhn, M., L'Homme, A., Mohring, M.P., Merhi, B. Abou, Boulos, J., El Masri, H., Halut, C.
- Nutrition 2016 v.32 no.2 pp. 206-212
- casein, casein hydrolysates, children, feces, immunoglobulin E, infant formulas, infants, milk, milk allergy, skin prick tests
- Cow's milk allergy (CMA) is treated in formula-fed infants with an extensive protein hydrolysate. This study aimed to evaluate the nutritional safety of a non-thickened and thickened extensively casein hydrolyzed protein formula (NT- and T-eCHF) in infants with CMA.Infants younger than 6 mo old with a positive cow milk challenge test, positive IgE, or skin prick test for cow milk were selected. Weight and length were followed during the 6 mo intervention with the NT-eCHF and T-eCHF.A challenge was performed in 50/71 infants with suspected CMA and was positive in 34/50. All children with confirmed CMA tolerated the eCHF. The T-eCHF leads to a significant improvement of the stool consistency in the whole population and in the subpopulation of infants with proven CMA. Height and weight evolution was satisfactory throughout the 6 mo study.The eCHF fulfills the criteria of a hypoallergenic formula and the NT- and T-eCHF reduced CMA symptoms. Growth was within normal range.