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Metal–Organic Frameworks as Efficient Oral Detoxifying Agents

Author:
Rojas, Sara, Baati, Tarek, Njim, Leila, Manchego, Lisbeth, Neffati, Fadoua, Abdeljelil, Nissem, Saguem, Saad, Serre, Christian, Najjar, Mohamed Fadhel, Zakhama, Abdelfateh, Horcajada, Patricia
Source:
Journal of the American Chemical Society 2018 v.140 no.30 pp. 9581-9586
ISSN:
1520-5126
Subject:
adsorbents, coordination polymers, decontamination, drugs, gastrointestinal system, histology, intestinal absorption, oral administration, overdose, poisoning, toxicity
Abstract:
Poisoning and accidental oral intoxication are major health problems worldwide. Considering the insufficient efficacy of the currently available detoxification treatments, a pioneering oral detoxifying adsorbent agent based on a single biocompatible metal–organic framework (MOF) is here proposed for the efficient decontamination of drugs commonly implicated in accidental or voluntary poisoning. Furthermore, the in vivo toxicity and biodistribution of a MOF via oral administration have been investigated for the first time. Orally administered upon a salicylate overdose, this MOF is able to reduce the salicylate gastrointestinal absorption and toxicity more than 40-fold (avoiding histological damage) while exhibiting exceptional gastrointestinal stability (<9% degradation), poor intestinal permeation, and safety.
Agid:
6079135