PubAg

Main content area

Branch-Selective and Enantioselective Iridium-Catalyzed Alkene Hydroarylation via Anilide-Directed C–H Oxidative Addition

Author:
Grélaud, Simon, Cooper, Phillippa, Feron, Lyman J., Bower, John F.
Source:
Journal of the American Chemical Society 2018 v.140 no.30 pp. 9351-9356
ISSN:
1520-5126
Subject:
enantioselectivity
Abstract:
Tertiary benzylic stereocenters are accessed in high enantioselectivity by Ir-catalyzed branch selective addition of anilide ortho-C–H bonds across styrenes and α-olefins. Mechanistic studies indicate that the stereocenter generating step is reversible.
Agid:
6079139