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Synthesis of optically active macrolides with hydrazide fragments from tetrahydropyran and L-(+)-tartaric acid derivatives

Author:
Ishmuratov, G. Yu., Yakovleva, M. P., Mingaleeva, G. R., Shutova, M. A., Muslukhov, R. R., Vyrypaev, E. M., Tolstikov, A. G.
Source:
Chemistry of natural compounds 2013 v.49 no.4 pp. 691-693
ISSN:
0009-3130
Subject:
acids, hydrazides, macrolides, synthesis
Abstract:
The synthesis of two potentially useful optically active 23- and 30-membered macrolides containing a 1,2-diol system and dihydrazide fragments was developed starting from tetrahydropyran. It was based on [1+1]-condensation of 7-oxooctyl-7-oxooctanoate and bis(7-oxooctyl)hexanedioate with L-(+)-tartaric acid hydrazide.
Agid:
608166