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Microevolution and independent incursions as main forces shaping H5 Hemagglutinin diversity during a H5N8/H5N5 highly pathogenic avian influenza outbreak in Czech Republic in 2017
- Nagy, Alexander, Dán, Ádám, Černíková, Lenka, Vitásková, Eliška, Křivda, Vlastimil, Horníčková, Jitka, Masopust, Roman, Sedlák, Kamil
- Archives of virology 2018 v.163 no.8 pp. 2219-2224
- avian influenza, ecoregions, hemagglutinins, viruses, Czech Republic
- Here, we present a comprehensive analysis of the H5N8/H5N5 highly pathogenic avian influenza (HPAI) virus strains detected in the Czech Republic during an outbreak in 2017. Network analysis of the H5 Hemagglutinin (HA) from 99% of the outbreak localities suggested that the diversity of the Czech H5N8/H5N5 viruses was influenced by two basic forces: local microevolution and independent incursions. The geographical occurrence of the central node H5 HA sequences revealed three eco-regions, which apparently played an important role in the origin and further spread of the local H5N8/HPAI variants across the country. A plausible explanation for the observed pattern of diversity is also provided.