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Addition of N-Heterocyclic Carbene Catalyst to Aryl Esters Induces Remote C–Si Bond Activation and Benzylic Carbon Functionalization

Author:
Wang, Hongling, Chen, Xingkuan, Li, Yongjia, Wang, Jilan, Wu, Shuquan, Xue, Wei, Yang, Song, Chi, Yonggui Robin
Source:
Organic letters 2018 v.20 no.2 pp. 333-336
ISSN:
1523-7052
Subject:
carbenes, carbon, carboxylic esters, catalysts, chemical bonding, chemical reactions, chemical structure, heterocyclic nitrogen compounds, silicon
Abstract:
Through the incorporation of a silicon atom to an aryl carboxylic ester substrate, the resulting C–Si bond can be activated via the addition of a carbene catalyst on a remote site. This strategy allows for efficient functionalization of the benzylic sp³-carbons of aryl carboxylic esters.
Agid:
6083287