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Photoredox-Catalyzed Decarboxylative Alkylation of Silyl Enol Ethers To Synthesize Functionalized Aryl Alkyl Ketones
- Kong, Weiguang, Yu, Changjiang, An, Hejun, Song, Qiuling
- Organic letters 2018 v.20 no.2 pp. 349-352
- alkylation, chemical structure, indomethacin, ketones, phthalimide, silyl enol ethers, stearic acid
- Photoredox-catalyzed decarboxylative alkylation of silyl enol ethers has been developed. Diverse functionalized aryl alkyl ketones were afforded in modest to good yields using N-(acyloxy)phthalimide as an easy access alkyl radical source under mild and operationally simple conditions. The excellent performance of drug molecules such as fenbufen and indomethacin and naturally occurring carboxylic acids such as stearic acid and dehydrocholic acid further demonstrated the practicability of the reaction.