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A [4 + 3] Annulation Reaction of aza-o-Quinone Methides with Arylcarbohydrazonoyl Chlorides for Synthesis of 2,3-Dihydro-1H-benzo[e][1,2,4]triazepines

Author:
Guo, Zhenyan, Jia, Hao, Liu, Honglei, Wang, Qijun, Huang, Jiaxing, Guo, Hongchao
Source:
Organic letters 2018 v.20 no.10 pp. 2939-2943
ISSN:
1523-7052
Subject:
chemical reactions, chemical structure, chlorides, organochlorine compounds
Abstract:
An unprecedented [4 + 3] annulation reaction of aza-ortho-quinone methides with arylcarbohydrazonoyl chlorides has been achieved under mild conditions. The annulation underwent a sequential conjugate addition/intramolecular annulation/rearrangement, providing a useful method for the synthesis of biologically interesting 2,3-dihydro-1H-benzo[e][1,2,4]triazepine.
Agid:
6083941