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Magterpenoids A–C, Three Polycyclic Meroterpenoids with PTP1B Inhibitory Activity from the Bark of Magnolia officinalis var. biloba

Author:
Li, Chuan, Li, Chuang-Jun, Ma, Jie, Chen, Fang-You, Li, Li, Wang, Xiao-Liang, Ye, Fei, Zhang, Dong-Ming
Source:
Organic letters 2018 v.20 no.12 pp. 3682-3686
ISSN:
1523-7052
Subject:
Magnolia officinalis var. biloba, bark, chemical reactions, inhibitory concentration 50, moieties, monoterpenoids, quinones
Abstract:
Magterpenoid A (1), possessing a rare 4,6,11-trioxatricyclo[5.3.1.0¹,⁵]undecane framework with an irregular monoterpenoid moiety, magterpenoid B (2), with an unprecedented 6/6/6/6 polycyclic skeleton, and magterpenoid C (3), a novel terpenoid quinone with a C6–C3 unit, were isolated from the bark of Magnolia officinalis var. biloba. Plausible biogenetic pathways of 1-3 are presented. Compounds 1 and 3 exhibited significant PTP1B inhibitory activities with IC₅₀ values of 1.44 and 0.81 μM, respectively.
Agid:
6084152