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Synthetic Studies on the Natural Product Myrsinoic Acid F Reveal Biologically Active Analogues

Author:
Mikusek, Jiri, Nugent, Jeremy, Ward, Jas S., Schwartz, Brett D., Findlay, Alison D., Foot, Jonathan S., Banwell, Martin G.
Source:
Organic letters 2018 v.20 no.13 pp. 3984-3987
ISSN:
1523-7052
Subject:
chemical reactions, cis-trans isomers, ears, edema, indomethacin, mice, nonsteroidal anti-inflammatory agents, synthesis
Abstract:
The synthesis of the structure, 1, assigned to the anti-inflammatory natural product myrsinoic acid F is reported together with a means for preparing its Z-isomer 21. While neither of these compounds corresponds to the natural product, both of them are anti-inflammatory agents (as determined using a mouse ear edema assay) with congener 1 being notably more potent than the widely prescribed NSAID indometacin.
Agid:
6084183