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Asymmetric [4 + 2]-Cycloaddition of Copper–Allenylidenes with Hexahydro-1,3,5-triazines: Access to Chiral Tetrahydroquinazolines

Author:
Ji, Danqing, Wang, Cheng, Sun, Jiangtao
Source:
Organic letters 2018 v.20 no.12 pp. 3710-3713
ISSN:
1523-7052
Subject:
chemical reactions, chemical structure, enantioselectivity, organic compounds
Abstract:
A copper-catalyzed asymmetric formal [4 + 2]-cycloaddition of copper–allenylidenes and hexahydro-1,3,5-triazines has been developed, providing chiral tetrahydroquinazolines in moderate to good yields and with high enantioselectivities for most cases (up to 88% yield and 98% ee).
Agid:
6084195