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Nickel-Catalyzed Arylative Carboxylation of Alkynes with Arylmagnesium Reagents and Carbon Dioxide Leading to Trisubstituted Acrylic Acids
- Wang, Sheng, Xi, Chanjuan
- Organic letters 2018 v.20 no.13 pp. 4131-4134
- alkynes, carbon dioxide, carboxylation, moieties, regioselectivity
- Nickel-catalyzed arylcarboxylation of alkynes with arylmagnesium reagents and carbon dioxide (CO₂, 1 atm) was realized in one pot. Various trisubstituted acrylic acids within an aryl group at the β-position have been prepared efficiently with good regioselectivity under mild conditions. The resulting products could be further transformed to benzoannelated cycles retaining CO₂ as a one-carbon synthon.