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Structure elucidation and antitumour activity of a new macrolactam produced by marine-derived actinomycete Micromonospora sp. FIM05328

Author:
Nie, Yi-Lei, Wu, Yun-Dan, Wang, Chuan-Xi, Lin, Ru, Xie, Yang, Fang, Dong-Sheng, Jiang, Hong, Lian, Yun-Yang
Source:
Natural product research 2018 v.32 no.18 pp. 2133-2138
ISSN:
1478-6427
Subject:
Micromonospora, antibacterial properties, antineoplastic activity, bacteria, fungi, human cell lines, metabolites, neoplasm cells, nuclear magnetic resonance spectroscopy, pyridones, East China Sea
Abstract:
Chemical investigation of a marine-derived actinomycete strain Micromonospora sp. FIM05328 isolated from a soil sample collected from the East China Sea, resulted in the discovery of a new 26-membered polyene macrolactam metabolite FW05328-1 (1), together with a known polyene with pyridone ring compound aurodox (2). The structures of compounds 1 and 2 were determined by the detailed analysis of 1D, 2D NMR and HR-TOF-MS data, along with literature data analysis. 1 and 2 exhibited excellent antiproliferative activities against KYSE30, KYSE180 and EC109 human tumour cell lines, but displayed no antibacterial activities against bacteria or fungi were tested.
Agid:
6087390