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Degradable Carbon Dots with Broad-Spectrum Antibacterial Activity

Author:
Li, Hao, Huang, Jian, Song, Yuxiang, Zhang, Mengling, Wang, Huibo, Lu, Fang, Huang, Hui, Liu, Yang, Dai, Xing, Gu, Zonglin, Yang, Zaixing, Zhou, Ruhong, Kang, Zhenhui
Source:
ACS applied materials & interfaces 2018 v.10 no.32 pp. 26936-26946
ISSN:
1944-8252
Subject:
DNA, RNA, air, antibacterial properties, antibiotics, antifungal properties, ascorbic acid, bacteria, carbon dioxide, carbon monoxide, carbon quantum dots, electrochemistry, fungi, gene expression, human health, nanomedicine, pollution, temperature, toxicity
Abstract:
The infection of bacteria and fungus is one of the most challenging global threats to human health. With the recent advancement in nanoscience and nanotechnology, much progress has been achieved in the development of antimicrobial nanomedicine; however, these nanomaterial-based antibacterial agents still suffer from potential biological toxicity, poor degradation, and various secondary pollution. Here, we demonstrate the fabrication of low-toxic and degradable carbon dots (CDs) from vitamin C by one-step electrochemical method. These newly generated CDs display a strong broad-spectrum antibacterial activity and antifungal activity even at low concentrations, as they destroy the bacterial walls during the diffusive entrance, perturb secondary structures of DNA/RNAs of bacteria and fungus, and inhibit important gene expressions to finally kill the bacteria and fungus. We also show that these well-characterized CDs can be completely degraded into CO₂, CO and H₂O under visible light in air (or at very mild temperature, about 37 °C).
Agid:
6089519