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Ruthenium-Promoted C–H Activation Reactions between DNA-Conjugated Acrylamide and Aromatic Acids
- Wang, Xuan, Sun, Hui, Liu, Jiaxiang, Dai, Dongcheng, Zhang, Mingqiang, Zhou, Hu, Zhong, Wenge, Lu, Xiaojie
- Organic letters 2018 v.20 no.16 pp. 4764-4768
- DNA, acrylamides, aromatic acids, carbon-hydrogen bond activation, chemical reactions, chemical structure
- The first example of DNA-compatible C–H activation reaction between DNA-conjugated acrylamides and aromatic acids has been developed. This new transformation enables aromatic acid, previously considered as monofunctional building block, to act like a bifunctional building block for the DNA encoded library synthesis. The general scope of aromatic acid was established for this new on-DNA C–H activation, which paved the way for its application in combinatorial library preparation.