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Fabrication of charge reversible graphene oxide-based nanocomposite with multiple antibacterial modes and magnetic recyclability

Li, Qiang, Yong, Chunyan, Cao, Weiwei, Wang, Xi, Wang, Lina, Zhou, Jie, Xing, Xiaodong
Journal of colloid and interface science 2018 v.511 pp. 285-295
Escherichia coli, Fourier transform infrared spectroscopy, Raman spectroscopy, Staphylococcus aureus, X-ray diffraction, antibacterial properties, cytotoxicity, graphene, graphene oxide, iron oxides, magnetic separation, magnetism, nanocomposites, nanoparticles, nanosilver, pH, polymers, transmission electron microscopes, transmission electron microscopy
In this work, N-alkylated poly (4-vinylpyridine) (NPVP), a cationic polymer, was firstly applied for the surface modification of Fe3O4 nanoparticles. Then the modified Fe3O4 nanoparticles (Fe3O4@NPVP NPs) combined with graphene oxide (GO) through simple electrostatic binding. Subsequently, deposited Ag nanoparticles (Ag NPs) procedure was carried out to form the multiple antibacterial nanocomposites (GO-Fe3O4@NPVP-Ag). The synthesized nanostructures were well characterized by Transmission Electron Microscope (TEM), X-ray powder diffraction (XRD), Fourier-transform infrared (FT-IR) and Raman spectroscopy. The zeta potentialmeasurement showed that the novel antibacterial nanocomposites exhibited a capacity of reversing its surface charge from negative (physiological pH) to positive (acidic condition). Furthermore, the incorporation of magnetic Fe3O4 NPs into the nanosystems facilitates the cyclic utilization of GO-Fe3O4@NPVP-Ag by magnetic separation. The antibacterial properties of GO-Fe3O4@NPVP-Ag nanocomposites were evaluated with Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. Moreover, the cytotoxicity of GO-Fe3O4@NPVP-Ag nanocomposites was studied using NIH-3T3 cells. The results showed that the GO-Fe3O4@NPVP-Ag nanocomposites exhibited excellent antibacterial properties and low cytotoxicity, thus confirming its application as a promising rapid bactericide in various antibacterial fields.