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Copper-catalyzed annulation of 2-bromobenzoic esters with terminal alkynes towards 3-substituted isocoumarins

Author:
Sun, Mengli, Su, Lebin, Dong, Jianyu, Liu, Long, Zhou, Yongbo, Yin, Shuang-Feng
Source:
Tetrahedron letters 2017 v.58 no.25 pp. 2433-2437
ISSN:
0040-4039
Subject:
alkynes, chemical reactions, copper, esters, isocoumarins, moieties, regioselectivity
Abstract:
An efficient method for the synthesis of 3-substituted isocoumarins that are an important class of biologically active scaffolds via annulation of 2-bromobenzoic esters with terminal alkynes by copper catalyzed is described. The advantages of this method include mild reaction conditions, high yield and regioselectivity, and wide tolerance toward functional groups.
Agid:
6097563