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Oxidation for unsymmetrical bromo-1,10-phenanthrolines and subsequent hydroxylation, decarbonylation and chlorination reactions

Author:
Peng, Yu-Xin, Hu, Bin, Huang, Wei
Source:
Tetrahedron 2018
ISSN:
0040-4020
Subject:
chemical structure, chlorination, hydroxylation, organic compounds, oxidation, regioselectivity, temperature
Abstract:
A systematic investigation on the oxidation of unsymmetric bromo-phens is presented herein, where the reaction temperature is found to be the key parameter to generate oxidation or oxidation-bromination products. The regioselective C3-brominated compounds are produced in moderate yields in the cases of 2-bromo-phen and 4-bromo-phen. Subsequent hydroxylation and decarbonylation for bromo-phds are also studied, where a series of bromo-diazafluorenones and phen-triones have been isolated. Furthermore, various chlorination products have been obtained by treating bromo-phds or bromo-phts with excess POCl3.
Agid:
6097628