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Synthesis of (Z)-nitroalkene derivatives through oxidative dehydrogenation coupling of α-aminocarbonyl compounds with nitromethane by copper catalysis
- Zhu, Menghua, Chen, De, Zeng, Sheng, Xing, Chenhu, Deng, Wei, Xiang, Jiannan, Wang, Rui-Jia
- Tetrahedron letters 2018 v.59 no.33 pp. 3214-3219
- carbonyl compounds, catalytic activity, chemical bonding, chemical structure, copper, dehydrogenation, stereoselectivity
- A novel copper-catalyzed cross-dehydrogenative coupling reaction of α-amino carbonyl compounds with nitromethane to synthesis of (Z)-nitroalkene derivatives has been established. (Z)-Nitroalkene derivatives are achieved through the cleavage of sp³ CsbndH bonds and formation of CsbndC double bond, with mild reaction conditions and excellent stereoselectivity.