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Abyssomicin Monomers and Dimers from the Marine-Derived Streptomyces koyangensis SCSIO 5802

Author:
Huang, Hongbo, Song, Yongxiang, Li, Xin, Wang, Xin, Ling, Chunyao, Qin, Xiangjing, Zhou, Zhenbin, Li, Qinglian, Wei, Xiaoyi, Ju, Jianhua
Source:
Journal of natural products 2018 v.81 no.8 pp. 1892-1898
ISSN:
1520-6025
Subject:
Streptomyces, Vesiculovirus, antibiotic resistance, biosynthesis, methicillin, methicillin-resistant Staphylococcus aureus
Abstract:
Three new abyssomicin monomers designated neoabyssomicins D (1), E (2), and A2 (3) and the two dimeric neoabyssomicins F (4) and G (5) were discovered from the marine-derived Streptomyces koyangensis SCSIO 5802, and their structures rigorously elucidated. Neoabyssomicin D (1) possesses an unprecedented 8/5/5/7 ring skeleton, the biosynthesis of which (as well as 2) is proposed herein. Additionally, dimeric agents 4 and 5 were found to be active against methicillin-resistant Staphylococcus aureus and vesicular stomatitis virus, respectively.
Agid:
6098264