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Platelets, On Your Marks, Get Set, Migrate!

Author:
Bambach, Sarah K., Lämmermann, Tim
Source:
Cell 2017 v.171 no.6 pp. 1256-1258
ISSN:
0092-8674
Subject:
bacteria, blood platelets, liver, thrombosis
Abstract:
The idea that anucleate platelets display autonomous migration has long been viewed with skepticism. Gaertner et al. provide in vivo evidence that platelets undergo active migration at sites of thrombus formation and in inflamed liver sinusoids. Integrin-dependent migration allows platelets to scavenge and bundle fibrin-bound material, including intravascular bacteria.
Agid:
6099009