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Magnetic field-inducible drug-eluting nanoparticles for image-guided thermo-chemotherapy

Author:
Thirunavukkarasu, Guru Karthikeyan, Cherukula, Kondareddy, Lee, Hwangjae, Jeong, Yong Yeon, Park, In-Kyu, Lee, Jae Young
Source:
Biomaterials 2018 v.180 pp. 240-252
ISSN:
0142-9612
Subject:
colorectal neoplasms, doxorubicin, drug therapy, fever, heat, image analysis, in vitro studies, in vivo studies, iron oxides, magnetic fields, magnetic resonance imaging, nanoparticles, neoplasm cells, polymers
Abstract:
Multifunctional nanoparticles integrating cancer cell imaging and treatment modalities into a single platform are recognized as a promising approach; however, their development currently remains a challenge. In this study, we synthesized magnetic field-inducible drug-eluting nanoparticles (MIDENs) by embedding superparamagnetic iron oxide nanoparticles (Fe₃O₄; SPIONs) and cancer therapeutic drugs (doxorubicin; DOX) in a temperature-responsive poly (lactic-co-glycolic acid) (PLGA) nanomatrix. Application of an external alternating magnetic field (AMF) generated heat above 42 °C and subsequent transition of the PLGA polymer matrix (Tg = 42–45 °C) from the glassy to the rubbery state, facilitating the controlled release of the loaded DOX, ultimately allowing for simultaneous hyperthermia and local heat-triggered chemotherapy for efficient dual cancer treatment. The average size of the synthesized MIDENs was 172.1 ± 3.20 nm in diameter. In vitro studies showed that the MIDENs were cytocompatible and especially effective in destroying CT26 colon cancer cells with AMF application. In vivo studies revealed that the MIDENs enabled enhanced T₂ contrast magnetic resonance imaging and a significant suppression of malignant tumor growth under an AMF. Our multifunctional MIDENs, composed of biocompatible substances and therapeutic/imaging modalities, will be greatly beneficial for cancer image-guided thermo-chemotherapy applications.
Agid:
6100959