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Effects of three infusion fluids with different sodium chloride contents on steady‐state serum concentrations of bromide in dogs

Fukunaga, Koya, Matsumoto, Hikaru, Wate, Michiko, Misawa, Karin, Saito, Miyoko, Matsuda, Hiroshi, Orito, Kensuke
Journal of veterinary pharmacology and therapeutics 2018 v.41 no.5 pp. 684-690
Beagle, blood serum, dogs, epilepsy, overdose, potassium bromide, protocols, renal clearance, sodium, sodium chloride, urine
Potassium bromide overdose (bromism) in the management of canine epilepsy has been known. However, a protocol to reduce bromide concentrations rapidly has not been previously established. The effects of three infusion fluids with different chloride contents on the steady‐state serum concentrations of bromide in beagles were determined. After stabilization of the serum bromide concentrations, seven dogs were infused with saline (Na⁺ 154 mmol/L; Cl⁻ 154 mmol/L), lactated Ringer's (Na⁺ 131 mmol/L; Cl⁻ 110 mmol/L), or maintenance solutions (Na⁺ 35 mmol/L; Cl⁻ 35 mmol/L) at a rate of 2 or 10 ml kg⁻¹ hr⁻¹ for 5 hr. Serum and urine were collected hourly, and the bromide concentrations were measured. When saline and lactated Ringer's solutions were infused at a rate of 10 ml kg⁻¹ hr⁻¹ for 5 hr, serum bromide concentrations were decreased by 14.24% and urine bromide concentrations by 17.63%, respectively. Of all compositions of infusion fluids, only sodium and chloride contents were associated with the decreased serum concentrations and the increased renal clearance of bromide. In summary, saline and lactated Ringer's solutions reduced serum bromide concentrations in a sodium chloride‐dependent manner in dogs were found when infused at 10 ml kg⁻¹ hr⁻¹ for 5 hr.