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Antimicrobial peptide encapsulation and sustained release from polymer network particles prepared in supercritical carbon dioxide

Author:
Parilti, Rahmet, Caprasse, Jérémie, Riva, Raphaël, Alexandre, Michaël, Vandegaart, Hélène, Bebrone, Carine, Dupont-Gillain, Christine, Howdle, Steven M., Jérôme, Christine
Source:
Journal of colloid and interface science 2018 v.532 pp. 112-117
ISSN:
0021-9797
Subject:
antimicrobial peptides, carbon dioxide, encapsulation, polymerization, polymers
Abstract:
Antimicrobial peptide loaded poly(2-hydroxyethyl methacrylate) particles were synthesized in supercritical carbon dioxide via one-pot free-radical dispersion polymerisation of 2-hydroxyethyl methacrylate and a cross-linker. Discrete particles with a well-defined spherical morphology and a diameter as low as 450 nm have been obtained in mild conditions. The encapsulation and release of the peptide were confirmed by antimicrobial tests that demonstrated for the first time a sustained release of the peptide from poly(2-hydroxyethyl methacrylate) microgels prepared by one-pot dispersion polymerization in supercritical carbon dioxide and then dispersed in water.
Agid:
6103322