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A single exercise bout augments adenovirus-specific T-cell mobilization and function
- Kunz, Hawley E., Spielmann, Guillaume, Agha, Nadia H., O'Connor, Daniel P., Bollard, Catherine M., Simpson, Richard J.
- Physiology & behavior 2018 v.194 pp. 56-65
- Adenoviridae, Herpesviridae, T-lymphocytes, adjuvants, antigens, cell transplantation, exercise, hematopoietic stem cells, manufacturing, morbidity, mortality, viruses
- Adoptive transfer of virus-specific T-cells (VSTs) effectively treats viral infections following allogeneic hematopoietic stem cell transplantation (alloHSCT), but logistical difficulties have limited widespread availability of VSTs as a post-transplant therapeutic. A single exercise bout mobilizes VSTs specific for latent herpesviruses (i.e. CMV and EBV) to peripheral blood and augments their ex vivo expansion. We investigated whether exercise exerts similar effects on T-cells specific for a NON-latent virus such as adenovirus, which is a major contributor to infection-related morbidity and mortality after alloHSCT. Thirty minutes of cycling exercise increased circulating adenovirus-specific T-cells 2.0-fold and augmented their ex vivo expansion by ~33% compared to rest without altering antigen and MHC-specific autologous target cell killing capabilities. We conclude that exercise is a simple and economical adjuvant to boost the isolation and manufacture of therapeutic VSTs specific to latent and non-latent viruses from healthy donors.