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Protective effects of a natural herbal compound quercetin against snake venom-induced hepatic and renal toxicities in rats

Author:
Al-Asmari, Abdulrahman K., Khan, Haseeb A., Manthiri, Rajamohamed A., Al-Khlaiwi, Ahmad A., Al-Asmari, Bayan A., Ibrahim, Khalid E.
Source:
Food and chemical toxicology 2018 v.118 pp. 105-110
ISSN:
0278-6915
Subject:
Echis, antidotes, atrophy, biomarkers, blood serum, hepatocytes, histopathology, kidneys, lipid peroxidation, liver, oxidative stress, protective effect, quercetin, rats, renal function, snake venoms, snakes, thiols, toxicity, toxicology
Abstract:
Echis pyramidum is a highly poisonous viper snake. Previous studies have shown acute phase hepatic and renal toxicities of Echis pyramidum venom (EPV) in rats. This study reports the protective effects of a natural herbal compound quercetin (QRC) on EPV-induced hepatic and renal toxicities in rats. A singly injection of EPV (4.76 mg/kg) caused significant increase in serum biomarkers of liver and kidney function. Pre-treatment of QRC (10 mg/kg) significantly reduced the toxic effects of EPV on functional impairment in liver and kidneys of rats. Administration of QRC also reversed EPV-induced increase in lipid peroxidation and decrease in total thiols. The histopathology of liver showed fat accumulation, focal degeneration and cytoplasmic vacuolation of hepatocytes in EPV treated rats. EPV also caused renal tubular dilation and focal atrophy of glomerular tufts in rat kidneys. Administration of QRC prevented EPV-induced structural tissue damage in liver and kidneys of rats. In conclusion, QRC significantly inhibited the acute phase toxic effects of EPV on liver and kidneys of rats by preventing the oxidative stress in these organs. QRC is also known for its anti-inflammatory, anti-edema, anti-hemorrhagic and PLA2-inhibitory properties and therefore may be regarded as a multi-action antidote against snake venom toxicity.
Agid:
6106172