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ESR2 gene G1730A variant is associated with triglycerides level and myocardial infarction in young men but not in women
- Ambroziak, Michał, Kuryłowicz, Alina, Roszkowska-Gancarz, Małgorzata, Budaj, Andrzej
- Gene 2018 v.677 pp. 83-88
- estrogen receptors, genes, genotype, males, men, myocardial infarction, patients, restriction fragment length polymorphism, risk factors, triacylglycerols, women
- The aim of the study was to investigate the role of estrogen receptor type 2 gene (ESR2) variant G1730A in myocardial infarction (MI) in young age.Genotyping was performed with restriction fragments length polymorphism method in 158 patients (79.1% men) with MI aged <50 years (studied group) and in control groups: 150 healthy individuals aged <50 years (63.3% men) and 202 patients (64.3% men) with MI aged ≥50 years.The AA genotype of ESR2 G1730A variant was significantly more frequent in men with MI aged <50 comparing to men with MI aged ≥50 (21.6% vs. 8.4%, P = 0.004) and to healthy young men (21.6% vs. 11.6%, P = 0.048). There was statistically significant difference between AA genotype and GA + GG genotypes male carriers with MI aged <50 in median triglyceride (TG) level (2.0 vs. 1.7 mmol/l respectively, p = 0.023).Our findings suggest a possible role of ESR2 G1730A variant as the risk factor of MI in a young age not as an independent but a potential risk factor associated with TG level in men but not in women.