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ESR2 gene G1730A variant is associated with triglycerides level and myocardial infarction in young men but not in women

Ambroziak, Michał, Kuryłowicz, Alina, Roszkowska-Gancarz, Małgorzata, Budaj, Andrzej
Gene 2018 v.677 pp. 83-88
estrogen receptors, genes, genotype, males, men, myocardial infarction, patients, restriction fragment length polymorphism, risk factors, triacylglycerols, women
The aim of the study was to investigate the role of estrogen receptor type 2 gene (ESR2) variant G1730A in myocardial infarction (MI) in young age.Genotyping was performed with restriction fragments length polymorphism method in 158 patients (79.1% men) with MI aged <50 years (studied group) and in control groups: 150 healthy individuals aged <50 years (63.3% men) and 202 patients (64.3% men) with MI aged ≥50 years.The AA genotype of ESR2 G1730A variant was significantly more frequent in men with MI aged <50 comparing to men with MI aged ≥50 (21.6% vs. 8.4%, P = 0.004) and to healthy young men (21.6% vs. 11.6%, P = 0.048). There was statistically significant difference between AA genotype and GA + GG genotypes male carriers with MI aged <50 in median triglyceride (TG) level (2.0 vs. 1.7 mmol/l respectively, p = 0.023).Our findings suggest a possible role of ESR2 G1730A variant as the risk factor of MI in a young age not as an independent but a potential risk factor associated with TG level in men but not in women.