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Value of glycolic acid analysis in ethylene glycol poisoning: A clinical case report and systematic review of the literature

Tuero, Gaspar, González, Jesús, Sahuquillo, Laura, Freixa, Anna, Gomila, Isabel, Elorza, Miguel Ángel, Barceló, Bernardino
Forensic science international 2018 v.290 pp. e9
blood serum, case studies, ethylene glycol, gibberellic acid, glycolic acid, mortality, odds ratio, patients, poisoning, prognosis, systematic review, urine
To evaluate the clinical utility of glycolic acid (GA) determination in the diagnosis and prognosis of ethylene glycol (EG) intoxications.Systematic review of serum and/or urine GA concentrations available in the literature in cases of EG poisoning. Present a clinical case in which the determination of the GA was decisive.In total, 137 patients were included. Serum GA concentrations (but not EG) of patients who survive are different from those who die. The optimal cut-off of serum GA to predict mortality was 990.5mg/L (sensitivity 85.2%, specificity 54.3%) with an Odds Ratio of 6.838 (2.868–16.302). In our clinical case, serum EG was negative; however, urine GA was positive (1230.7mg/L).In all suspected cases of EG poisoning, it is advisable to carry out the simultaneous analysis of EG and GA.