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Paeoniflorin attenuates LPS-induced inflammation in nucleus pulposus cells via Nrf-2/HO-1/HMGB1/NF-κB pathway
- Heng, Yin, Mao, Wu, Yong, Ma, Yang, Guo, Su, Qiuju, Wang, Jianwei
- Microbial pathogenesis 2018
- inflammation, interleukin-1beta, interleukin-6, lipopolysaccharides, malondialdehyde, protein content, superoxide dismutase, tumor necrosis factor-alpha
- This study was to investigate the effects of paeoniflorin (PA) on lipopolysaccharides (LPS)-induced nucleus pulposus cells. Our results demonstrated that PA significantly reduced lipopolysaccharides (LPS) induced inflammatory factors including interleukin-1β (IL-1β), tumor necrosis Factor-α (TNF-α) and interleukin-6 (IL-6) in nucleus pulposus cells. PA also decreased of malondialdehyde (MDA) and increased superoxide dismutase (SOD) induced by LPS. Moreover, the expression of the protein levels of Nrf-2/HO-1/HMGB1/NF-κB were increased after LPS challenge, which were significantly restored after PA. Our results demonstrated PA reduced LPS-mediated inflammation in nucleus pulposus.