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Orange juice allied to a reduced-calorie diet results in weight loss and ameliorates obesity-related biomarkers: A randomized controlled trial

Author:
Ribeiro, Carolina, Dourado, Grace, Cesar, Thais
Source:
Nutrition 2017 v.38 pp. 13-19
ISSN:
0899-9007
Subject:
C-reactive protein, adverse effects, ascorbic acid, biomarkers, body fat, body mass index, energy, epidemiological studies, folic acid, food intake, glucose, homeostasis, insulin, insulin resistance, lipid composition, lipid metabolism, low density lipoprotein cholesterol, models, nutrients, nutritional adequacy, obesity, orange juice, patients, protein content, randomized clinical trials, sugar content, waist-to-hip ratio, weight gain, weight loss
Abstract:
Assumptions have linked orange juice (OJ) consumption with weight gain and adverse effects on health due to its sugar content; however, epidemiologic studies have not shown increased risk for overweight or obesity with the consumption of 100% OJ. The aim of this study was to verify whether the combination of a reduced-calorie diet (RCD) and 100% OJ contribute to weight loss, promote changes in glucose and lipid metabolism, and improve diet quality in obese individuals.A randomized controlled trial with 78 obese patients (age 36 ± 1 y, body mass index [BMI] 33 ± 3 kg/m²) were enrolled in two groups: Individuals in the OJ group submitted to an RCD that included OJ (500 mL/d), and individuals in the control group submitted to an RCD without OJ. Body composition, biochemical biomarkers, and dietary intake were analyzed over a 12-wk period.Both treatments had similar outcomes regarding body weight (−6.5 kg; P = 0.363), BMI (−2.5 kg/m²; P = 0.34), lean mass (−1 kg; P = 0.29), fat mass (−5 kg; P = 0.58), body fat (−3%; P = 0.15), and waist-to-hip ratio (−0.1; P = 0.79). Insulin levels in the OJ group decreased by 18% (P = 0.05), homeostasis model assessment–insulin resistance by 33% (P = 0.04), total cholesterol by 24% (P = 0.004), low-density lipoprotein cholesterol by 24% (P ≤ 0.001), and high-sensitivity C-reactive protein levels by 33% (P = 0.001) compared with the control group. Consumption of energy and nutrients was similar between the two groups, but vitamin C and folate increased by 62% (P ≤ 0.015) and 39% (P = 0.033), respectively, after OJ intervention.When consumed concomitantly with an RCD, OJ does not inhibit weight loss; ameliorate the insulin sensitivity, lipid profile, or inflammatory status, or contribute nutritionally to the quality of the diet.
Agid:
6111710