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First report of extensively-drug-resistant Proteus mirabilis isolate carrying plasmid-mediated blaNDM-1 in a Tunisian intensive care unit

Author:
Kanzari, Lamia, Ferjani, Sana, Saidani, Mabrouka, Hamzaoui, Zeineb, Jendoubi, Ali, Harbaoui, Sarra, Ferjani, Asma, Rehaiem, Amel, Boutiba Ben Boubaker, Ilhem, Slim, Amine
Source:
International journal of antimicrobial agents 2018 v.52 no.6 pp. 906-909
ISSN:
0924-8579
Subject:
Proteus mirabilis, aminoglycosides, beta-lactamase, carbapenems, cephalosporins, colistin, fluoroquinolones, genes, tigecycline
Abstract:
Emergence of the New Delhi metallo-β-lactamase (NDM-1), an Ambler class B metallo-β-lactamase able to hydrolyse all β-lactams except monobactams, constitutes a critical and increasingly important medical issue. The acquisition of blaNDM-1 is of particular concern for Proteus mirabilis, which is intrinsically resistant to tetracycline, tigecycline and colistin, as this will make clinical treatment extremely difficult. To the authors’ knowledge, this is the first report of the blaNDM-1 gene in an extensively-drug-resistant P. mirabilis clinical isolate carrying plasmid-mediated resistance to carbapenems (blaNDM-1), cephalosporins (blaCMY-4), aminoglycosides (aph3 VIa and aph3 Ia) and fluoroquinolones (qnrA6).
Agid:
6112152