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Epithelial-mesenchymal transition as a target for botanicals in cancer metastasis
- Salehi, Bahare, Varoni, Elena Maria, Sharifi-Rad, Mehdi, Rajabi, Sadegh, Zucca, Paolo, Iriti, Marcello, Sharifi-Rad, Javad
- Phytomedicine 2019 v.55 pp. 125-136
- antineoplastic agents, metastasis, neoplasms, phenylpropanoids, phytopharmaceuticals, phytotherapy, plant products
- The plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery.In this view, epithelial-mesenchymal transition (EMT) represents a novel and major target in anticancer therapy. Therefore, this narrative review aims to provide an updated overview on the bioactive phytochemicals with anti-EMT activity.Among the plant products reviewed, phenylpropanoids were the most investigated at preclinical phase, thus exhibiting a promising potential as anticancer drugs, though an evidence-based clinical efficacy is still lacking.