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Engineering nanoreactors using bacterial microcompartment architectures
- Plegaria, Jefferson S, Kerfeld, Cheryl A
- Current opinion in biotechnology 2018 v.51 pp. 1-7
- bioengineering, carbon, carbon dioxide, carbon dioxide fixation, encapsulation, enzymes, metabolism, multigene family, organelles
- Bacterial microcompartments (BMCs) are organelles that encapsulate enzymes involved in CO2 fixation or carbon catabolism in a selectively permeable protein shell. Here, we highlight recent advances in the bioengineering of these protein-based nanoreactors in heterologous systems, including transfer and expression of BMC gene clusters, the production of template empty shells, and the encapsulation of non-native enzymes.