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Fucoxanthin ameliorates hyperglycemia, hyperlipidemia and insulin resistance in diabetic mice partially through IRS-1/PI3K/Akt and AMPK pathways

Zhang, Yiping, Xu, Wen, Huang, Xiaoqiang, Zhao, Youqin, Ren, Qiangqiang, Hong, Zhuan, Huang, Mingqing, Xing, Xia
Journal of functional foods 2018 v.48 pp. 515-524
animal disease models, blood glucose, blood lipids, carnitine palmitoyltransferase, diabetes, diet, drugs, fatty-acid synthase, functional foods, glucokinase, glucose, glucose transporters, glycogen, glycogen (starch) synthase, histology, hyperglycemia, hyperlipidemia, insulin resistance, lipid metabolism, liver, messenger RNA, mice, peroxisome proliferator-activated receptors, skeletal muscle
Fucoxanthin has potential anti-diabetic activities, but its precise effects and underlying mechanisms remain unclear. In this study, C57BL/KsJ-db/db mice were fed diets containing fucoxanthin (0.2% and 0.4%, w/w) for 6 weeks. Results showed dietary fucoxanthin significantly improved glucose/lipid metabolism and insulin resistance, and prevented pancreatic histological changes in db/db mice. Moreover, fucoxanthin markedly lowered blood glucose by regulating glucokinase and phosphoenolpyruvate carboxykinase mRNA expressions in liver, promoted glycogen synthesis by regulating glucose transporter 4, glycogen synthase and glycogen synthase kinase-3 beta protein expressions in skeletal muscle, and lowered blood lipid levels by regulating peroxisome proliferator-activated receptor alpha, p-acetyl CoA carboxylase, carnitine palmitoyltransferase 1 and fatty acid synthetase protein expressions in liver. Mechanistic studies indicated that fucoxanthin effectively regulates the expression of IRS-1/PI3K/AKT and AMPK signaling proteins in liver and skeletal muscle. All results suggested that fucoxanthin is a potential functional food or effective drug for type 2 diabetes mellitus.