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Determination of Non-Narcotic Analgetics by HPLC with Preconcentration on Triton X-100 Induced Phases

Author:
Fedorchuk, O. I., Kulichenko, S. A.
Source:
Journal of analytical chemistry 2018 v.73 no.9 pp. 917-921
ISSN:
1061-9348
Subject:
additives, benzoic acids, high performance liquid chromatography, indomethacin, octoxynol, pH, urine
Abstract:
The induced micellar-extraction preconcentration of mefenamic acid, naproxen, and indomethacin on Triton X-100 phases in the presence of salicylic and benzoic acids is studied. The optimal conditions for the preconcentration of analgetics are found: the pH of the solutions and the concentration of analytes. The maximum extraction of analgetics is observed at pH < pKₐ of the analyte and modifier. An increase in the recovery of analgetics with a decrease in their concentration in the initial solution is shown. A procedure for the determination of non-narcotic analgetics by HPLC with preliminary micellar-extraction concentration on Triton X-100 induced phases is developed. The procedure was used to analyze an urine sample with additives.
Agid:
6126600